Effect of prophylactic indomethacin in extremely low birth weight infants

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Prophylactic indomethacin and intestinal perforation in extremely low birth weight infants.

OBJECTIVE Prophylactic indomethacin reduces severe intraventricular hemorrhage but may increase spontaneous intestinal perforation (SIP) in extremely low birth weight (ELBW) infants. Early feedings improve nutritional outcomes but may increase the risk of SIP. Despite their benefits, use of these therapies varies largely by physician preferences in part because of the concern for SIP. METHODS...

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Effects of prophylactic indomethacin in extremely low-birth-weight infants with and without adequate exposure to antenatal corticosteroids.

OBJECTIVE To examine whether treatment with antenatal corticosteroids modifies the immediate and long-term effects of prophylactic indomethacin sodium trihydrate in extremely low-birth-weight infants. DESIGN Post hoc subgroup analysis of data from the Trial of Indomethacin Prophylaxis in Preterms. SETTING Thirty-two neonatal intensive care units in Canada, the United States, Australia, New ...

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Hypothyroxinemia in extremely low birth weight infants

Hypothyroxinemia of prematurity (HOP) is a transient alteration in thyroid hormone availabilityfound in more than half of extremely low birth weight infants (ELBW) born at less than 30 weeks [1]. HOP is characterized by very low total T4 (TT4) and free T4 (FT4) levels with a normal or low thyroid stimulating hormone (TSH); TT4 and FT4 show a nadir at 7-10 days of life and they may remained low ...

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Minerals and extremely low birth weight infants

The 80% of bone mineralisation occurs in the third trimester of pregnancy. The daily fetal requirement is 310 mg of calcium and 170 mg of phosphorus [1]. The bone mineral density (BMD) correlates positively with gestational age, weight and length [2]. At birth, extremely premature infants (ELBWI)canpresent hypocalcaemia because of interruption of the maternal calcium supply, high level of calci...

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Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.

BACKGROUND The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g). Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not kn...

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ژورنال

عنوان ژورنال: Korean Journal of Pediatrics

سال: 2006

ISSN: 1738-1061

DOI: 10.3345/kjp.2006.49.9.959